Synthesis and applications of chiral bis-THF in asymmetric synthesis

The synthesis of enantiopure bis-THF is described, starting from d-mannitol. Bis-THF is used as chiral ligand for organolithium reagents in four different reactions. The enantioselectivity provided by this ligand is moderate, and the asymmetric induction is in line with the expected model.     

Solubility parameter determination of cationic surfactants by inverse GC

Summary The solubility parameters of cationic surfactants were obtained using the inverse gas chromatographic technique. The surfactants didodecyl dimethyl ammonium bromide, dioctadecyl dimethyl ammonium bromide and dodecyl pyridinium chloride were used as stationary phase and retention data of different probe solutes were measured at different temperatures. The results were analysed by the combination of Flory-Huggins and Hildebrand theories, and the solubility parameters of the surfactants were obtained in a range of temperatures between 80–120°C.     

HPLC with amperometric detection for the determination of pesticides of high polarity

A relatively simple procedure is described for the selective and highly sensitive determination of amitrole (3-amino-1,2,4-triazole) by ionpair HPLC with amperometric detection. The separation was achieved on a polar CN-column using hexane, propanol, water (62:36:2) with LiClO₄ (2.5 g·l^–1) and trichloroacetic acid (2 g·l^–1) as electrolytes. The determination range lies between 500 pg and 500 ng and the limit of detection was found to be 200 pg (s.d.: 11%; N=9). The minimum detectability for the alternative UV-monitoring was 2.5 ng. The developed method may be helpful in production and quality control and for the selective determination of amitrole in commercial formulations.